HUMAN OTIC PROGENITOR CELL MODELS OF CONGENITAL HEARING LOSS REVEAL POTENTIAL PATHOPHYSIOLOGIC MECHANISMS OF ZIKA VIRUS AND CYTOMEGALOVIRUS INFECTIONS

ABSTRACTCongenital hearing loss is a common chronic condition affecting children in both developed and developing nations.Viruses correlated with congenital hearing loss include human cytomegalovirus (HCMV) and Zika virus (ZIKV), which causes congenital Zika syndrome.The mechanisms by which HCMV and ZIKV infections cause hearing loss are poorly und

Herpes simplex virus 1 (HSV-1) expresses a large number of miRNAs, and their function is still not completely understood.In addition, HSV-1 has been found to deregulate host miRNAs, which adds to cli the complexity of the regulation of efficient virus replication.In this study, we comprehensively addressed the deregulation of host miRNAs by massive

In this study, we report the copper-catalyzed synthesis of tetrahydroquinoline derivatives via Kiteboarding Lesson a domino reaction of aniline with cyclobutanone oxime.This method demonstrates a selective approach for generating bioactive tetrahydroquinoline scaffolds, which have broad applications in pharmaceutical chemistry.The reaction conditio

This study was conducted to show the effect of compression wood on some anatomical Sport Backpack characteristics and mechanical characteristics of brutia pine Pinus brutia Ten.trees growing naturally at Dohuk provenance and to compare it with the standing trees (tree leaning type) for four levels of stem height, and between compression wood and op